Sertraline is a commonly prescribed medicine used in the treatment of depression
People taking the antidepressant sertraline are being urged to seek medical help if they experience a number of serious symptoms. Sertraline, a commonly prescribed medication used to treat depression, panic disorder, social anxiety disorder, obsessive-compulsive disorder (OCD), and more, is a type of selective serotonin reuptake inhibitor (SSRI) that works by increasing the level of serotonin in the brain.
Serotonin, a crucial chemical that helps regulate mood, can help individuals feel calmer and happier when at optimal levels. Typically, sertraline is dispensed as a tablet to be swallowed, with dosages varying based on individual prescriptions.
While sertraline can be an effective treatment for people with depression and other conditions, it does come with a number of side effects, some of which may necessitate a call to 111. NHS guidance emphasises that not everyone who takes sertraline will experience side effects, and many of these may only last for a few weeks while your body adjusts to the new medication.
Despite this, people taking sertraline may experience the following side effects:
- Diarrhoea
- Putting on weight
- Dry mouth
- Sleeping difficulties
- Dizziness
- Drowsiness
- Nausea
- Vomiting
- Headaches
- Low sex drive
These side effects are typically mild and it is not usually necessary to consult a doctor or pharmacist unless they significantly bother you or don’t disappear on their own. However, the NHS advises dialling 111 for certain side effects.
It highlights you should dial 111 if “you’re taking sertraline and think you might be having serious side effects” or if “you’re having thoughts about harming yourself”. Serious side effects associated with sertraline can include:
- Feeling extremely low and having suicidal thoughts
- Anaphylaxis – a serious allergic reaction that can result in symptoms such as a swollen tongue or throat, difficulty breathing, or a raised, itchy rash
- Fast heartbeat, shaking, twitching muscles, confusion, or feeling agitated – these can be symptoms of serotonin syndrome
It’s crucial to remember that this is not an exhaustive list of potential side effects from taking sertraline. A full list of side effects associated with your medication can be found in the leaflet included in the medicine’s packet.
If you’re experiencing side effects from sertraline, you might be considering stopping the medication. However, the NHS strongly recommends that you continue taking the drug unless a healthcare professional advises otherwise.
If your GP suggests that you stop taking sertraline, they will likely advise you to slowly lower your dose over a period of weeks or months. This is to prevent withdrawal symptoms from suddenly stopping the medication.
Full NHS guidelines on sertraline can be found online here.















