Inital investigations indicate that tourists are among those killed in the wildfire, according to local media.
There are campsites in the Los Gallardos area including the large-scale Miraflores where people have been evacuated.
Residents also in Almocáizar, Fuente del Albarico, Los Pinos, La Serena and El Pinar de Bédar have also been told to leave their properties.
The emergency has closed the A-7 motorway northbound (from kilometre 709 to 714) and the N-340A national highway near the fire.